Pharmacological Screening of Substituted Benzimidazole Derivatives

In the present study some substituted benzimidazole derivatives were screened for several biological activities. The synthesized compounds subjected to evaluation of central analgesic, anti-inflammatory, cytotoxicity, antimicrobial and antioxidant activities by radiant heat induced tail flicking, carrageenan rat paw edema inhibition, brine shrimp lethality bioassay, disc diffusion DPPH free radical scavenging methods, respectively. Compounds 2a, 2c 2d elongated flicking time 58.07-, 51.59- 76.65%, respectively (p < 0.001) at 50 mg/kg body weight dose compared standard morphine (87.17%). 2b, showed prominent anti-inflammatory activity 100 (% inhibition 81.75%, 79.09% 86.69%, respectively) aceclofenac (87.83%). Among derivatives, 1a, 1b, 1c, 2a exhibited potent cytotoxicity with IC50 values 5.47-, 11.92-, 4.55-, 7.63- 7.94 μg/ml, addition, 1c displayed mild moderate zone (8-12 mm). On other hand, 1a 1b very 12.25 × 103 μg/ml 87.33 ×103 μg/ml. all 2c, can be potential candidates designing new anti-cancer agents in future.
 Dhaka Univ. J. Pharm. Sci. 20(1): 95-102, 2021 (June)